This week in therapeutics

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Target/marker/pathway

Summary

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Infectious disease

Influenza

Protectin D1 (PD1)

In vitro and mouse studies suggest PD1 could help treat influenza. In normal lung epithelial cells infected with influenza A virus, a lipid screen identified the lipid mediator PD1 as a suppressor of influenza replication. In mice, i.v. treatment with PD1 48 hours after infection increased survival compared with vehicle treatment. In the mouse model, PD1 plus the neuraminidase (NEU1; SIAL1) inhibitor peramivir led to 100% survival. Next steps could include testing PD1 in different animal models of influenza virus infection.
BioCryst Pharmaceuticals Inc. discontinued a Phase III trial of peramivir in November 2012 for futility following an interim analysis.

SciBX 6(11); doi:10.1038/scibx.2013.268
Published online March 21, 2013

Patent and licensing status unavailable

Morita, M. et al. Cell; published online March 7, 2013;
doi:10.1016/j.cell.2013.02.027
Contact: Yumiko Imai, Akita University, Akita, Japan
e-mail:
imai@med.akita-u.ac.jp