This week in therapeutics

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Inflammation

Inflammation

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Mouse and human studies suggest some mouse models for inflammatory disease may be less relevant than previously thought. In mouse models for inflammation caused by burns, trauma, endotoxemia and sepsis, a comparison of gene expression profiles showed poor correlation with corresponding expression profiles from human tissues undergoing similar insults. Next steps could include developing mouse models for inflammatory diseases with gene expression patterns that more closely match those seen in human tissue.

SciBX 6(9); doi:10.1038/scibx.2013.219
Published online March 7, 2013

Patent and licensing status undisclosed

Seok, J. et al. Proc. Natl. Acad. Sci. USA; published online Feb. 11, 2013;
doi:10.1073/pnas.1222878110
Contact: Ronald W. Davis, Stanford University, Palo Alto, Calif.
e-mail:

dbowe@stanford.edu