Indication

Target/marker/pathway

Summary

Licensing status

Publication and contact information

Transplantation

Bone marrow transplant

Epidermal growth factor (EGF)

Mouse studies suggest EGF could be useful in aiding recovery after bone marrow transplant. In irradiated mice, EGF increased hematopoietic stem cell (HSC) regeneration and survival compared with vehicle. In these mice, genetic or pharmacological disruption of EGF signaling decreased HSC regeneration and survival compared with no disruption. Next steps include scaling up EGF manufacturing and conducting preclinical studies comparing its efficacy with that of granulocyte colony-stimulating factor (G-CSF; CSF3), the standard of care for HSC mobilization after myeloablative therapy.

SciBX 6(8); doi:10.1038/scibx.2013.201
Published online Feb. 28, 2013

Patent pending; available for licensing

Doan, P.L. et al. Nat. Med.; published online Feb. 3, 2013;
doi:10.1038/nm.3070
Contact: John P. Chute, Duke University, Durham, N.C.
e-mail:
john.chute@duke.edu