Indication

Target/marker/pathway

Summary

Licensing status

Publication and contact information

Cancer

Colorectal cancer

Jagged 1 (JAG1)

Cell culture studies suggest blocking soluble JAG1 could help treat colorectal cancer by targeting cancer stem cells. In human colorectal cancer cell lines incubated in endothelial cell-conditioned medium, antibody-mediated depletion of soluble JAG1 decreased the formation of cells with a cancer stem cell phenotype compared with no depletion. Next steps could include evaluating JAG1-targeting antibodies in combination with existing therapies in mouse models of colorectal cancer.

SciBX 6(8); doi:10.1038/scibx.2013.192
Published online Feb. 28, 2013

Patent and licensing status unavailable

Lu, J. et al. Cancer Cell; published online Jan. 31, 2013;
doi:10.1016/j.ccr.2012.12.021
Contact: Lee M. Ellis, The University of Texas MD Anderson Cancer Center, Houston, Texas
e-mail:
lellis@mdanderson.org