Indication

Target/marker/pathway

Summary

Licensing status

Publication and contact information

Neurology

Depression; anxiety

Dopamine signaling

Mouse studies suggest blocking neurotransmission of dopamine-sensing neurons could help treat neuropsychiatric disorders triggered by chronic stress. In wild-type mice subjected to chronic stress-inducing social defeat, the generic small molecule quinpirole decreased the activity of dopamine-sensing neurons and led to increased social interaction compared with vehicle control. Next steps include developing compounds that selectively target dopamine signaling to treat neuropsychiatric disorders (see Stressing out over depression and anxiety, page 5).

SciBX 6(6); doi:10.1038/scibx.2013.143
Published online Feb. 14, 2013

Unpatented; unavailable for licensing

Barik, J. et al. Science; published online Jan. 18, 2013;
doi:10.1126/science.1226767
Contact: François Tronche, Pierre and Marie Curie University, Paris, France

e-mail:

francois.tronche@upmc.fr

Contact: Jacques Barik, same affiliation as above

e-mail:

jacques.barik@snv.jussieu.fr