Indication

Target/marker/pathway

Summary

Licensing status

Publication and contact information

Inflammation

Inflammation

Elastase

In vitro studies identified elastase inhibitors that could help treat inflammation. In enzymatic assays, marine cyanobacterium-derived molecules called symplostatins inhibited human neutrophil elastase (NE; ELA-2) with potency comparable to that of the marketed inhibitor sivelestat. In bronchial epithelial cells, the lead compound prevented elastase-induced inflammation with potency comparable to that of sivelestat. Next steps could include further optimization of the new compounds for in vivo testing.
Ono Pharmaceutical Co. Ltd. markets sivelestat to treat acute lung injury.

SciBX 6(6); doi:10.1038/scibx.2013.142
Published online Feb. 14, 2013

Patent and licensing status unavailable

Salvador, L.A. et al. J. Med. Chem.; published online Jan. 28, 2013;
doi:10.1021/jm3017305
Contact: Hendrik Luesch, University of Florida, Gainesville, Fla.
e-mail:

luesch@cop.ufl.edu