This week in therapeutics

Indication

Target/marker/pathway

Summary

Licensing status

Publication and
contact information

Infectious disease

Bacterial infection

Not applicable

In vitro studies identified a short, membrane-disrupting peptide that could help treat bacterial infections. In vitro, the D(KLAKLAK)2 peptide caused lipid bilayer disruption, was active against drug-resistant strains of Gram-negative bacteria and inhibited Pseudomonas aeruginosa biofilm growth with an MIC50 of 600 mg/mL. Next steps include conducting good laboratory practice (GLP) toxicology in rodents and primates and testing in models of severe infections.

SciBX 6(5); doi:10.1038/scibx.2013.117
Published online Feb. 7, 2013

Patent and licensing status undisclosed

McGrath, D.M. et al. Proc. Natl. Acad. Sci. USA; published online Jan. 23, 2012;
doi:10.1073/pnas.1221924110
Contact: Wadih Arap, The University of Texas MD Anderson Cancer Center, Houston, Texas
e-mail:
warap@mdanderson.org
Contact: Renata Pasqualini, same affiliation as above
e-mail:
rpasqual@mdanderson.org
Contact: Richard L. Sidman, Harvard Medical School, Boston, Mass.
e-mail:
richard_sidman@hms.harvard.edu