This week in therapeutics

Indication

Target/marker/pathway

Summary

Licensing status

Publication and contact information

Infectious disease

Malaria; sepsis

HMG-CoA reductase

Mouse studies suggest statins could help prevent malaria- and sepsis-associated cognitive dysfunction. In mouse models of malaria infection, the generic malaria drug chloroquine plus Mevacor lovastatin decreased neuroinflammation and cognitive impairment compared with chloroquine alone. In a mouse model of bacterial sepsis, antibiotics plus Mevacor decreased cognitive impairment compared with antibiotics alone. Next steps include starting clinical trials of statin drugs to prevent malaria or bacterial sepsis-associated cognitive impairment.
Merck & Co. Inc. markets Mevacor, an HMG-CoA reductase inhibitor, to treat hypercholesterolemia and reduce the risk of cardiovascular diseases.

SciBX 6(3); doi:10.1038/scibx.2013.58
Published online Jan. 24, 2013

Unpatented; licensing status not applicable

Reis, P.A. et al. PLoS Pathog.; published online Dec. 27, 2012;
doi:10.1371/journal.ppat.1003099
Contact: Patricia A. Reis, Oswaldo Cruz Foundation,
Rio de Janeiro, Brazil
e-mail:

reispa@gmail.com