Indication

Target/marker/pathway

Summary

Licensing status

Publication and contact information

Neurology

Alzheimer's disease (AD)

Amyloid precursor protein (APP)

Studies in mice suggest preventing the accumulation of the C99 peptide fragment of APP could help prevent or treat AD. In brain tissue from a mouse model of AD, immunohistochemical staining revealed intracellular aggregates of C99, a partially cleaved form of APP that is the precursor of b-amyloid (Ab). Next steps include testing for the presence of C99 in brain tissue from patients with AD and controls.

SciBX 5(48); doi:10.1038/scibx.2012.1260
Published online Dec. 13, 2012

Unpatented; licensing status not applicable

Lauritzen, I. et al. J. Neurosci.; published online Nov. 14, 2012;
doi:10.1523/JNEUROSCI.2775-12.2012
Contact: Frédéric Checler, University of Nice Sophia Antipolis, Nice, France
e-mail:
checler@ipmc.cnrs.fr