Indication

Target/marker/pathway

Summary

Licensing status

Publication and contact information

Endocrine/metabolic disease

Metabolic disease; obesity

Phosphoenolpyruvate carboxykinase 1 (PCK1)

A zebrafish screening study identified metabolic activators that could protect against obesity-related metabolic dysregulation. A high throughput screening study using transgenic reporter zebrafish identified two ligands that increased Pck1 promoter activity compared with vehicle. In mice with diet-induced obesity, subcutaneous injection of the lead ligand decreased hepatosteatosis and glucose intolerance compared with vehicle. Next steps include further characterizing the effects of the lead screening hit and using the zebrafish screen to identify more compounds with similar effects on metabolism.

SciBX 5(48); doi:10.1038/scibx.2012.1257
Published online Dec. 13, 2012

Unpatented; licensing status not applicable

Gut, P. et al. Nat. Chem. Biol.; published online Dec. 2, 2012;
doi:10.1038/nchembio.1136
Contact: Didier Y.R. Stainier, University of California, San Francisco, Calif.
e-mail:
didier.stainier@mpi-bn.mpg.de

Contact: Philipp Gut, same affiliation as above
e-mail:
philipp.gut@ucsf.edu