Indication

Target/marker/pathway

Summary

Licensing status

Publication and contact information

Cancer

Lung cancer

Oncostatin M (OSM)

Mouse studies suggest the cytokine OSM could help treat lung cancer. OSM is produced by mesenchymal stem cells and promotes differentiation. In cultured human lung cancer cell lines, OSM inhibited migration and invasion. In mice, injection of OSM-pretreated lung cancer cells followed by intratumoral dosing with the cytokine decreased tumor growth and metastasis compared with vehicle injection. Next steps include evaluating the combination of OSM and chemotherapy.

SciBX 5(48); doi:10.1038/scibx.2012.1255
Published online Dec. 13, 2012

Patent applications in progress; unavailable for licensing

Wang, M.-L. et al. Cancer Res.; published online Nov. 8, 2012;
doi:10.1158/0008-5472.CAN-12-1568
Contact: Cheng-Wen Wu, National Yang-Ming University, Taipei, Taiwan
e-mail:
cwwu@ym.edu.tw