Indication

Target/marker/pathway

Summary

Licensing status

Publication and contact information

Cancer

Cancer

Epsin 1 (EPN1); EPN2

Mouse studies suggest inhibiting EPN1 and EPN2 could help treat cancer. In mouse models of cancer, conditional knockout of Epn1 and Epn2 in vascular endothelial cells increased survival and decreased tumor growth, incidence and size compared with no knockout. Next steps include screening and testing compounds for activity against epsins.

SciBX 5(48); doi:10.1038/scibx.2012.1253
Published online Dec. 13, 2012

Patent application filed; available for licensing

Pasula, S. et al. J. Clin. Invest.; published online Nov. 26, 2012;
doi:10.1172/JCI64537
Contact: Hong Chen, Oklahoma Medical Research Foundation, Oklahoma City, Okla.
e-mail:
hong-chen@omrf.org