Indication

Target/marker/pathway

Summary

Licensing status

Publication and
contact information

Hepatic disease

Nonalcoholic steatohepatitis (NASH)

Protein peptidylprolyl cis/trans isomerase NIMA-interacting 1 (PIN1)

Mouse studies suggest inhibiting PIN1 could help treat and prevent NASH. In mice fed a NASH-inducing diet, Pin1 knockouts had lower markers of liver injury, inflammation and fibrosis than wild-type controls. Next steps could include developing PIN1 inhibitors and evaluating them in models of NASH.

SciBX 5(46); doi:10.1038/scibx.2012.1209
Published online Nov. 29, 2012

Patent and licensing status unavailable

Nakatsu, Y. et al. J. Biol. Chem.; published online Oct. 29, 2012;
doi:10.1074/jbc.M112.397133
Contact: Tomoichiro Asano, Hiroshima University, Hiroshima, Japan
e-mail:
asano-tky@umin.ac.jp