Indication

Target/marker/pathway

Summary

Licensing status

Publication and contact information

Neurology

Epilepsy;
seizures

Not applicable

Rat studies suggest blocking thalamocortical neuronal activity could help treat and prevent seizures. In rats, ipsilateral cortical stroke, which can lead to injury-induced epilepsy, increased excitability of thalamocortical neurons compared with that of neurons from the uninjured hemisphere. In epileptic rats experiencing a seizure, optogenetic inhibition of thalamocortical neurons caused immediate cessation of seizure activity and behaviors. Next steps include developing an optogenetic system that could be used for real-time control of seizures in humans.

SciBX 5(45); doi:10.1038/scibx.2012.1185
Published online Nov. 15, 2012

Unpatented; unavailable for licensing

Paz, J.T. et al. Nat. Neurosci.; published online Nov. 7, 2012;
doi:10.1038/nn.3269
Contact: John R. Huguenard, Stanford University School of Medicine, Stanford, Calif.
e-mail:

john.huguenard@stanford.edu