Indication

Target/marker/pathway

Summary

Licensing status

Publication and contact information

Cancer

Melanoma

Not applicable

Mouse studies identified a UV radiation-independent mechanism contributing to melanoma development in fair-skinned patients that could be blocked to prevent the disease. In a mouse model of BRAF-induced melanoma, mice with a mutation that upregulates the pigment pheomelanin had higher invasive melanoma incidence, even without UV exposure, than dark-skinned mice with low levels of pheomelanin or albino mice that lacked melanin. Mice with high levels of pheomelanin had more oxidative skin damage than mice with normal levels of pheomelanin. Next steps include identifying and testing antioxidants to prevent melanoma.

SciBX 5(45); doi:10.1038/scibx.2012.1183
Published online Nov. 15, 2012

Patent application filed; available for licensing

Mitra, D. et al. Nature; published online Oct. 31, 2012;
doi:10.1038/nature11624
Contact: David E. Fisher, Massachusetts General Hospital, Charlestown, Mass.
e-mail:

dfisher3@partners.org