Indication

Target/marker/pathway

Summary

Licensing status

Publication and contact information

Endocrine/metabolic disease

Diabetes

Serotonin; tryptophan hydroxylase 1 (TPH1; TPH)

Mouse studies suggest inhibiting synthesis of gut-derived serotonin through TPH1 could help treat type 2 diabetes. In mice, Tph1 deficiency, which leads to reduced synthesis of gut-derived serotonin, increased insulin and glucose tolerance compared with normal Tph1 expression. In mice fed a high-fat diet, pharmacological inhibition of Tph1 normalized insulin tolerance and increased glucose tolerance compared with no inhibition. Next steps could include identifying other targets for inhibiting gut-derived serotonin synthesis.

SciBX 5(44); doi:10.1038/scibx.2012.1158
Published online Nov. 8, 2012

Patent and licensing status unavailable

Sumara, G. et al. Cell Metab.; published online Oct. 18, 2012;
doi:10.1016/j.cmet.2012.09.014
Contact: Gerard Karsenty, Columbia University Medical Center, New York, N.Y.
e-mail:
gk2172@columbia.edu