Indication

Target/marker/pathway

Summary

Licensing status

Publication and contact information

Cancer

Melanoma

IL-9

Mouse studies suggest IL-9-producing T helper type 9 (Th9) cells could help treat melanoma. In a mouse model of melanoma, an IL-9-neutralizing antibody increased susceptibility to developing lung metastasis compared with IgG control. In the mouse melanoma model, adoptive transfer of Th9 cells led to smaller tumors than transfer of Th1 cells or vehicle. Next steps could include evaluating the adoptive transfer of Th9 cells in additional cancer models.

SciBX 5(43); doi:10.1038/scibx.2012.1135
Published online Nov. 1, 2012

Patent and licensing status unavailable

Lu, Y. et al. J. Clin. Invest.; published online Oct. 15, 2012;
doi:10.1172/JCI65459
Contact: Qing Yi, The University of Texas MD Anderson Cancer Center, Houston, Texas
e-mail:
qyi@mdanderson.org