Indication

Target/marker/pathway

Summary

Licensing status

Publication and contact information

Neurology

Pain

Protease-activated receptor 2 (PAR2)

Rodent studies suggest inhibiting PAR2 signaling could help treat cancer-associated pain. In mice, injection of supernatant from human squamous cell carcinomas induced acute mechanical allodynia in wild-type animals but not in Par2-deficient animals. In a mouse model of chemically induced squamous cell carcinoma in the mouth, a Par2 deficiency led to complete absence of cancer-induced chronic allodynia. Next steps include developing a PAR2 antagonist.

SciBX 5(41); doi:10.1038/scibx.2012.1092
Published online Oct. 18, 2012

Unpatented; licensing status not applicable

Lam, D.K. et al. J. Neurosci.; published online Oct. 10, 2012;
doi:10.1523/JNEUROSCI.2399-12.2012
Contact: Brian L. Schmidt, New York University College of Dentistry, New York, N.Y.
e-mail:
bls322@nyu.edu