Indication

Target/marker/pathway

Summary

Licensing status

Publication and contact information

Neurology

Alzheimer's disease (AD)

b-Amyloid 42

A high throughput screen identified small molecule inhibitors of b-amyloid 42 aggregation that could help treat AD. In rat neuronal cells, the lead inhibitor lowered b-amyloid 42-induced toxicity compared with no inhibitor. In a fruit fly model of AD, the inhibitor decreased locomotor deficits and increased lifespan compared with no treatment. Next steps include developing optimized derivatives and testing them in mouse models of AD.

SciBX 5(39); doi:10.1038/scibx.2012.1035
Published online Oct. 4, 2012

Unpatented; available for partnering and collaboration

McKoy, A.F. et al. J. Biol. Chem.; published online Sept. 19, 2012;
doi:10.1074/jbc.M112.348037
Contact: Michael H. Hecht, Princeton University, Princeton, N.J.
e-mail:

hecht@princeton.edu