Indication

Target/marker/pathway

Summary

Licensing status

Publication and contact information

Inflammation

Asthma

Solute carrier family 26 member 9 (SLC26A9)

A mouse and patient genetic study suggests activating SLC26A9 could help treat asthma-associated mucus obstruction. In genetic studies, SNPs located upstream of SLC26A9, which blunted gene expression in a cell-based assay, were associated with childhood asthma. In a mouse model of IL-13-induced asthma, Slc26a9 knockout mice had greater airway mucus obstruction than wild-type mice. Next steps include developing a pharmacological approach for activating SLC26A9 and identifying patients with asthma that have reduced SLC26A9 function.

SciBX 5(39); doi:10.1038/scibx.2012.1033
Published online Oct. 4, 2012

Unpatented; licensing status not applicable

Anagnostopoulou, P. et al. J. Clin. Invest.; published online Sept. 4, 2012;
doi:10.1172/JCI60429
Contact: Marcus A. Mall, Heidelberg University, Heidelberg, Germany
e-mail:

marcus.mall@med.uni-heidelberg.de