Indication

Target/marker/pathway

Summary

Licensing status

Publication and contact information

Cardiovascular disease

Thrombosis

Polyphosphate

In vitro and mouse studies identified inhibitors of polyphosphate that could help prevent thrombosis. In in vitro assays, polyphosphate inhibitors blocked the interaction between thrombin and polyphosphate and doubled the clotting times in human plasma compared with no inhibitor. In mouse models of venous and arterial thrombosis, the inhibitors prevented platelet and fibrin accumulation in the developing thrombi. Next steps include using this approach to identify a therapeutic candidate.

SciBX 5(38); doi:10.1038/scibx.2012.1003
Published online Sept. 27, 2012

Patent applications filed covering polyphosphate and its effects on hemostasis, thrombosis and inflammation; available for licensing

Smith, S.A. et al. Blood; published online Sept. 11, 2012;
doi:10.1182/blood-2012-07-444935
Contact: James H. Morrissey, University of Illinois at Urbana-Champaign, Urbana, Ill.
e-mail:
jhmorris@illinois.edu