Indication

Target/marker/pathway

Summary

Licensing status

Publication and contact information

Cancer

Multiple myeloma (MM)

Nicotinamide phosphoribosyltransferase (NAMPT)

Cell culture and mouse studies suggest inhibiting NAMPT could help treat MM. In MM cell lines and patient-derived cells, including cell lines resistant to current MM therapies, an NAMPT inhibitor decreased cell viability compared with no treatment. In mice with MM cells, the NAMPT inhibitor decreased tumor volume and increased survival compared with vehicle. Next steps could include optimizing the NAMPT inhibitor.

SciBX 5(38); doi:10.1038/scibx.2012.1002
Published online Sept. 27, 2012

Patent and licensing status unavailable

Cea, M. et al. Blood; published online
Sept. 5, 2012;
doi:10.1182/blood-2012-03-416776
Contact: Kenneth C. Anderson,
Dana-Farber Cancer Institute and Harvard Medical School, Boston, Mass.
e-mail:
kenneth_anderson@dfci.harvard.edu