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Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Acute myelogenous leukemia (AML) AML1-ETO oncogenic fusion protein; cyclooxygenase-2 (COX-2) In vitro and …
Published on 5/23/2013
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Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer B cell lymphoma Histone deacetylase (HDAC); proteasome Cell culture and mouse studies suggest a combination …
Published on 5/23/2013
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Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Brain cancer Integrin b1 (CD29) In vitro and mouse studies suggest CD29 inhibitors could help treat Avastin …
Published on 5/23/2013
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Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Breast cancer Ret proto-oncogene (RET) Studies in cell culture suggest inhibiting RET could be useful for …
Published on 5/23/2013
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Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Breast cancer Ribosomal protein S6 kinase 90 kDa polypeptide 2 (RPS6KA2; RSK3); RPS6KA6 (RSK4); …
Published on 5/23/2013
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Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Cancer Fibroblast activation protein (FAP) In vitro studies identified a boronic acid-based inhibitor of FAP…
Published on 5/23/2013
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Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Cancer Heat shock protein 90 (Hsp90); lysine-specific demethylase 4B (KDM4B; JMJD2B) Cell culture studies …
Published on 5/23/2013
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Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Cancer HER2 (EGFR2; ErbB2; neu) Mouse and cell culture studies have identified a HER2-specific aptamer that …
Published on 5/23/2013
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Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Cancer TTK protein kinase (TTK; MPS1) In vitro and rat studies suggest a new class of MPS1 inhibitors could …
Published on 5/23/2013
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Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Cancer Tubulin A mouse study suggests photodynamic therapy (PDT) with red light-activated prodrugs could …
Published on 5/23/2013
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Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Leukemia Telomerase reverse transcriptase (TERT) A mouse study suggests adoptive transfer of T cells …
Published on 5/23/2013
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Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Solid tumors Insulin-like growth factor-1 receptor (IGF1R; CD221); insulin receptor substrate 1 (IRS1); IRS2…
Published on 5/23/2013
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Indication Target/marker/pathway Summary Licensing status Publication and contact information Neurology Depression; pain Regulator of G-protein signaling 4 (RGS4) Mouse studies suggest modulating RGS4 …
Published on 5/23/2013
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Indication Target/marker/pathway Summary Licensing status Publication and contact information Neurology Neurology Histone deacetylase 2 (HDAC2) Mouse studies suggest inhibiting HDAC2 in the brain could help …
Published on 5/23/2013
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Indication Target/marker/pathway Summary Licensing status Publication and contact information Other Cushing's disease Nuclear receptor subfamily 2 group C member 2 (NR2C2; TR4) Patient sample and mouse …
Published on 5/23/2013
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Indication Target/marker/pathway Summary Licensing status Publication and contact information Various Bacterial infections; inflammation Lipopolysaccharide (LPS) Cell culture studies suggest a cathelicidin …
Published on 5/23/2013
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This week in therapeutics Indication Target/marker/pathway Summary Licensing status Publication and contact information Autoimmune disease Autoimmune disease IL-7; IL-7 receptor (IL-7R; CD127) In vitro and …
Published on 5/16/2013
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This week in therapeutics Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Acute myelogenous leukemia (AML) Hemopoietic cell kinase (HCK) SAR and mouse …
Published on 5/16/2013
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This week in therapeutics Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Brain cancer Dual-specificity tyrosine-(Y)-phosphorylation-regulated kinase 1A (…
Published on 5/16/2013
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This week in therapeutics Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Breast cancer b-Catenin (CTNNB1); HER2 (EGFR2; ErbB2; neu); p21 protein (Cdc42 Rac…
Published on 5/16/2013
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This week in therapeutics Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Breast cancer Discoidin domain receptor tyrosine kinase 2 (DDR2) In vitro and …
Published on 5/16/2013
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This week in therapeutics Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Cancer DNA In vitro and mouse studies suggest prodrugs of the duocarmycin family …
Published on 5/16/2013
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This week in therapeutics Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Cancer Enhancer of zeste homolog 2 (EZH2); SWI/SNF-related matrix-associated actin…
Published on 5/16/2013
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This week in therapeutics Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Cancer Insulin receptor substrate 1 (IRS1); phosphatidylinositol 3-kinase …
Published on 5/16/2013
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This week in therapeutics Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Cancer K-Ras; son of sevenless homolog 1 (SOS1); CRAF (RAF1) In vitro, cell …
Published on 5/16/2013