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Chronological Index of : Techniques

 Current Issue
  • Techniques: Implantable biopolymer scaffolds to enhance adoptive T cell therapy

    Drug delivery TECHNOLOGY: Polymers Implantable biopolymer scaffolds could enhance adoptive T cell therapy for treating cancer. Porous scaffolds were created from polymerized alginate plus silica microparticles and …

    Published on 1/8/2015
  • Techniques: Screen for combinations of tyrosine kinase inhibitors (TKI) effective in TKI-resistant lung cancers

    Assays and screens TECHNOLOGY: High throughput screening Cell culture and mouse studies suggest screening tumor biopsies from lung cancer patients with acquired resistance to a TKI could help identify TKI …

    Published on 1/8/2015
  • Techniques: Silk-based antibody delivery device for preventing post-surgical infection

    Drug delivery TECHNOLOGY: Polymers A silk-based device could enable sterilization of surgical sites and site-specific antibiotic delivery to prevent post-surgical infections. The device consists of a wirelessly …

    Published on 1/8/2015
  • Techniques: Tumor- and mitochondria-targeted agent

    Drug delivery TECHNOLOGY: Targeting Domains Mouse studies suggest a tumor- and mitochondria-targeted agent could help treat cancer and monitor treatment response. The agent contains four parts: a biotin receptor-…

    Published on 1/8/2015
  • Techniques: Chromosome 11 open reading frame 30 (C11orf30), calpain small subunit 1 (CAPNS1; CAPN14), signal transducer and activator of transcription 6 (STAT6) and ankyrin repeat ...

    Bio Markers TECHNOLOGY: Markers Genomewide association studies identified four genes that could serve as diagnostic markers and/or therapeutic targets for EoE. In a discovery cohort of 603 EoE patients and 3,637 …

    Published on 12/18/2014
  • Techniques: Extending therapeutic protein half-lives via fusion to affibodies with pH-dependent, binding to neonatal Fc receptor

    Drug platforms TECHNOLOGY: Drug platforms Fusing therapeutic proteins to affibodies with pH-dependent binding to neonatal Fc receptor could improve the proteins' half-lives. Binding to Fc receptors improves the half…

    Published on 12/18/2014
  • Techniques: MicroRNA let-7c (MIRLET7C; let-7c), microRNA-99a (miR-99a) and microRNA-125b (miR-125b) as prognostic markers of luminal breast cancer

    Bio Markers TECHNOLOGY: Markers Studies in patient samples and cell culture suggest let-7c, miR-99a and miR-125b could serve as prognostic markers in patients with estrogen receptor-positive luminal breast cancers. …

    Published on 12/18/2014
  • Techniques: Nanomolar-scale, high throughput chemical synthesis of drug-like molecules

    Chemistry TECHNOLOGY: Chemistry A high throughput, miniaturized chemical synthesis platform could enable rapid discovery of lead compounds. The robotic platform utilized DMSO-compatible palladium (Pd) catalysts to …

    Published on 12/18/2014
  • Techniques: RNA interference (RNAi) against therapeutic targets with short interfering ribonucleic neutrals (siRNNs)

    Drug platforms TECHNOLOGY: Drug platforms siRNNs could enable RNAi knockdown of therapeutic targets in a broader range of cells and tissue types than siRNA. siRNNs are siRNA-like oligonucleotides modified with …

    Published on 12/18/2014
  • Techniques: Tumor-selective delivery of antisense oligomers (antimiRs) against oncogenic microRNAs

    Drug platforms TECHNOLOGY: Tumor-selective delivery of antisense oligomers (antimiRs) against oncogenic microRNAs MicroRNA-targeted antimiRs conjugated to a peptide with a low pH-induced transmembrane structure (…

    Published on 12/18/2014
  • Techniques

    Approach Summary Licensing status Publication and contact information Assays & screens Chromatin immunoprecipitation with reference exogenous genome (ChIP-Rx) ChIP-Rx could be useful for epigenome profiling to …

    Published on 12/11/2014
  • Techniques

    Approach Summary Licensing status Publication and contact information Assays & screens Inducible Tet repressor protein (TetR)-RNA interaction system for control of Plasmodium falciparum gene expression A system …

    Published on 12/11/2014
  • Techniques

    Approach Summary Licensing status Publication and contact information Assays & screens Rapid diagnostic system to detect low levels of bacteria in blood The Integrated Comprehensive Droplet Digital Detection …

    Published on 12/11/2014
  • Techniques

    Approach Summary Licensing status Publication and contact information Disease models Mouse multiple myeloma (MM) model with constitutive IL-6 signal transducer (IL-6ST; gp130; CD130) expression Mice that …

    Published on 12/11/2014
  • Techniques

    Approach Summary Licensing status Publication and contact information Markers Mutant NRL family CARD domain containing 4 (NLRC4) as a marker of familial cold autoinflammatory syndrome (FCAS) Studies in patients …

    Published on 12/11/2014
  • Techniques

    Approach Summary Licensing status Publication and contact information Assays & screens Ex vivo detection of indirect therapeutic protein-small molecule drug interactions on the liver An ex vivo method for …

    Published on 12/4/2014
  • Techniques

    Approach Summary Licensing status Publication and contact information Assays & screens Screening for diabetic cardiomyopathy (DCM) therapies in induced pluripotent stem (iPS) cell-derived cardiomyocytes iPS cell…

    Published on 12/4/2014
  • Techniques

    Approach Summary Licensing status Publication and contact information Disease models Mice from the Collaborative Cross (CC) resource as models of Ebola viral infection Mice from the CC resource could help …

    Published on 12/4/2014
  • Techniques

    Approach Summary Licensing status Publication and contact information Disease models Mouse model of immune complex-mediated kidney disease A mouse model of immune complex-mediated kidney disease could help …

    Published on 12/4/2014
  • Techniques

    Approach Summary Licensing status Publication and contact information Drug platforms Automated, in vitro generation of specific neuronal subtypes from human pluripotent stem cells An automated, in vitro protocol…

    Published on 12/4/2014
  • Techniques

    Approach Summary Licensing status Publication and contact information Drug platforms Phage-assisted continuous evolution (PACE) to identify and predict drug-resistant protease mutations caused by protease …

    Published on 12/4/2014
  • Techniques

    Approach Summary Licensing status Publication and contact information Drug platforms Screening platform to produce high-affinity nanobodies A platform that uses high throughput DNA sequencing and mass …

    Published on 12/4/2014
  • Techniques

    Approach Summary Licensing status Publication and contact information Assays & screens Paper-based diagnostics using synthetic gene networks Cell-free synthetic gene networks embedded in paper discs could be …

    Published on 11/20/2014
  • Techniques

    Approach Summary Licensing status Publication and contact information Disease models Bioengineered, implantable scaffolds that recapitulate the human metastatic bone marrow microenvironment Bioengineered, …

    Published on 11/20/2014
  • Techniques

    Approach Summary Licensing status Publication and contact information Drug platforms Direct reprogramming of human fibroblasts to striatal medium spiny neurons (MSNs) Direct reprogramming of human fibroblasts to…

    Published on 11/20/2014

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