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Depletion of host hematopoietic stem cells (HSCs) in utero improves engraftment after liver mononuclear cell transplant in fetuses

Mouse studies suggest in utero depletion of HSCs can improve engraftment after liver mononuclear cell transplant. In fetal mice, a mouse anti-stem cell factor receptor tyrosine kinase (c-Kit; Kit; Cd117) antibody was shown to deplete HSCs. In fetal mice, depletion of HSCs with the mouse antibody prior to congenic liver mononuclear cell transplantation increased the rate and level of donor cell engraftment compared with no depletion. Next steps include using a humanized version of the antibody in in utero nonhuman primate bone marrow transplant models of hemoglobinopathies, such as thalassemia or sickle cell disease.

SciBX 7(27); doi:10.1038/scibx.2014.810
Published online July 17, 2014

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Derderian, S.C. et al. Blood;
published online May 30, 2014;
doi:10.1182/blood-2014-02-550327
Contact: Tippi C. MacKenzie, University of California,
San Francisco, Calif.
e-mail:
tippi.mackenzie@ucsfmedctr.org