Thursday, May 29, 2014
Publication and contact
Human embryonic stem cell-derived
cardiomyocytes (hESC-CMs) to treat ischemia/reperfusion injury
Nonhuman primate studies
suggest hESC-CM transplantation could be used to treat ischemia/reperfusion
injury. In a nonhuman primate model of ischemia/reperfusion injury, delivery
of one billion hESC-CMs to the infarct site resulted in their engraftment in
the host animal heart and subsequent maturation and perfusion by blood
vessels over a period of three months. In animals that received the
transplant, the grafts showed electromechanical coupling with the heart, but
ventricular arrhythmias were observed for the first two weeks after the
transplant. Next steps could include conducting studies using larger numbers
of animals to determine the mechanisms leading to the arrhythmias and doing a
more detailed assessment of cardiac function.
Published online May 29, 2014
Patent and licensing status
Chong, J.J.H. et al.
Nature; published online April 30, 2014;
Contact: Charles E. Murry, University of Washington, Seattle,
All contents Copyright © 1993-2015 BioCentury Publications, Inc. ALL RIGHTS RESERVED. All use of this Web Site and its contents is governed by the BioCentury User Agreement
. The contents of this Web Site are protected under U.S. and foreign copyright and intellectual property laws, and no part of this Web Site or its contents may be photocopied, reproduced or retransmitted in any form without the written consent of BioCentury, which may be requested from Reprints/Permissions
. BioCentury®; The Bernstein Report on BioBusiness™; The BioCentury 100™; The Clear Route to ROI™; Because Real Intelligence is Hard to Find™; BCIQ™; and BioPharma's Knowledge Center™; are trademarks of BioCentury Publications, Inc., P.O. Box 1246, San Carlos, CA 94070. SciBX® and SciBX: Science-Business eXchange® are trademarks of Nature America, Inc. that are jointly used by BioCentury Publications, Inc. and Nature America, Inc.
Thanks for purchasing this article.
Please bookmark this url for future reference.
We have also sent you a confirming e-mail with a receipt and this same url for your
close [ X ]