Thursday, April 3, 2014
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generated from fibroblasts with one pluripotency factor and four small
Cell culture studies
suggest cardiomyocytes for use in pharmacological screening and regenerative
therapies could be generated with minimal genetic manipulation. In mouse
embryonic and tail tip fibroblasts, expression of the pluripotency
transcription factor Oct4
plus a combination of four small molecules led to beating cardiomyocytes via
a cardiac precursor state without transition through a pluripotent state. The
cardiomyocytes expressed cardiac- and ventricular-specific markers and
exhibited a cross-striated pattern and electrophysiological ventricular
characteristics. Next steps include isolating and expanding a cardiac cell
population and translating the approach to human cardiomyocytes.
Published online April 3, 2014
Patent application filed;
available for licensing
Wang, H. et al. Cell
Rep.; published online Feb. 20, 2014;
Contact: Sheng Ding, Gladstone Institute of Cardiovascular
Disease, San Francisco, Calif.
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