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A transgenic, human pregnane X receptor (PXR)-expressing mouse model of type 2 diabetes

Transgenic mice expressing human PXR could be used to study the role of PXR in type 2 diabetes and screen for drugs to treat the indication. In mice fed a high-fat diet, transgenic expression of human PXR increased glucose intolerance, levels of circulating insulin and glucose and other symptoms of diabetes and decreased obesity compared with wild-type mouse Pxr expression. Future studies could include assessing PXR activity in tissues associated with human diabetes and using the transgenic model to screen for PXR inhibitors.

SciBX 7(5); doi:10.1038/scibx.2014.153
Published online Feb. 6, 2014

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Spruiell, K. et al. J. Biol. Chem.; published online Dec. 20, 2013;
doi:10.1074/jbc.M113.494575
Contact: Maxwell A. Gyamfi, North Carolina Central University, Durham, N.C.
e-mail:
mgyamfi@nccu.edu