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In vitro model to predict pharmacokinetic parameters important to antimalarial drug efficacy

An in vitro model to predict pharmacokinetic parameters important for antimalarial drug efficacy could help improve drug dosing. In a glass cartridge system, the ability of chloroquine to inhibit Plasmodium falciparum growth depended on minimum inhibitory concentration, whereas the ability of artemisinin to inhibit parasite growth depended on peak concentration (Cmax) of the drug. In a mouse model of malarial infection, the relationship between Cmax and the antimalarial activity of artemisinin was confirmed. Next steps include studying drug-resistant parasites and studying two drugs with different pharmacokinetic profiles at the same time.
Chloroquine and artemisinin are generic drugs used to treat malaria infection.

SciBX 6(43); doi:10.1038/scibx.2013.1239
Published online Nov. 7, 2013

Patent status undisclosed; licensing status not applicable

Bakshi, R.P. et al. Sci. Transl. Med.; published online Oct. 2, 2013;
doi:10.1126/scitranslmed.3006684
Contact: Theresa A. Shapiro, The Johns Hopkins University, Baltimore, Md.
e-mail:

tshapiro@jhmi.edu