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Major histocompatibility complex class I (MHC)-associated phosphopeptides to predict clinical outcome in leukemia

Tumor-associated phosphopeptides recognized by MHC could help predict outcomes for patients with leukemia. The phosphopeptide repertoires from 11 tumor samples representing multiple leukemia types were profiled for binding to MHC molecules. In samples from patients with leukemia, immune responses to the MHC-binding phosphopeptides were decreased compared with those of healthy donors. Patients without immune responses to the phosphopeptides had decreased survival compared with those who showed immune responses to the phosphopeptides. Next steps include developing phosphopeptide antigens for cancer immunotherapy.
PhosImmune Inc. is developing therapeutics and diagnostics related to this work.

SciBX 6(41); doi:10.1038/scibx.2013.1177
Published online Oct. 24, 2013

Patented; licensed to PhosImmune, a company spun-out of the University of Virginia School of Medicine

Cobbold, M. et al. Sci. Transl. Med.; published online Sept. 13, 2013;
doi:10.1126/scitranslmed.3006061
Contact: Victor H. Engelhard, University of Virginia, Charlottesville, Va.
e-mail:
vhe@virginia.edu

Contact: Mark Cobbold, University of Birmingham, Birmingham, U.K.
e-mail:
m.cobbold@bham.ac.uk