Approach

Summary

Licensing status

Publication and contact information

Disease models

Interferon regulatory factor 4 (Irf4)-deficient mouse models of chronic lymphocytic leukemia (CLL)

Irf4-deficient mice could be used to study CLL pathogenesis. In the New Zealand Black mouse strain, heterozygous deletion of Irf4 increased the number of animals that developed CLL within 12 months compared with wild-type Irf4 expression. In a different mouse strain, animals with homozygous deletion of Irf4 and knock-in of the IgG heavy chain Vh11 developed CLL with 100% penetrance within 10 months, whereas Vh11 knock-in models with heterozygous Irf4 deletion or normal Irf4 expression did not. Ongoing work includes using the models to elucidate how IRF4 contributes to the development of CLL.

SciBX 6(38); doi:10.1038/scibx.2013.1076
Published online Oct. 3, 2013

Findings from both studies unpatented; unlicensed

Ma, S. et al. J. Biol. Chem.; published online July 29, 2013;
doi:10.1074/jbc.M113.475913
Shukla, V. et al. Blood; published online Aug. 7, 2013;
doi:10.1182/blood-2013-03-492769
Contact: Runqing Lu, University of Nebraska Medical Center, Omaha, Neb.
e-mail:
rlu@unmc.edu