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Genetic markers of statin-induced myopathy

Genetic studies identified SNPs that could help stratify patients based on their risk for statin-induced myopathy. Use of statin drugs such as simvastatin is associated with a small increase in risk of myopathy. In an analysis of gene expression in lymphoblastoid cell lines derived from 480 subjects in a clinical trial of simvastatin, six SNPs at the glycine amidinotransferase (GATM; AGAT) gene locus were associated with decreased risk of statin-induced myopathy. Next steps include assessing the role of GATM in statin-mediated changes to cholesterol metabolism and muscle health.

SciBX 6(37); doi:10.1038/scibx.2013.1046
Published online Sept. 26, 2013

Unpatented; licensing status unavailable

Mangravite, L.M. et al. Nature; published online Aug. 28, 2013;
doi:10.1038/nature12508
Contact: Lara M. Mangravite,
Sage Bionetworks, Seattle, Wash.
e-mail:
lara.mangravite@sagebase.org