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Mice with epidermal-specific knockout of epidermal growth factor receptor (Egfr) to model skin toxicity associated with EGFR-targeted cancer therapy

Mice with epidermal-specific knockout of Egfr could help model skin rashes that develop in patients receiving EGFR inhibitors. In the mouse model, the number of inflammatory immune cells and the levels of proinflammatory cytokines in the skin were greater than those in Egfr-expressing animals, and defects in epidermal differentiation accumulated over time. In skin samples from patients undergoing EGFR-targeted therapy, comparable changes in inflammatory cell accumulation, levels of proinflammatory cytokines and skin barrier defects were observed. Next steps could include using the model to identify potential therapeutics that can target the inflammatory response in the skin.

SciBX 6(37); doi:10.1038/scibx.2013.1044
Published online Sept. 26, 2013

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Lichtenberger, B.M. et al. Sci. Transl. Med.; published online Aug. 21, 2013;
doi:10.1126/scitranslmed.3005886
Contact: Maria Sibilia, Medical University of Vienna, Vienna, Austria
e-mail:
maria.sibilia@meduniwien.ac.at
Contact: Bernhard Homey,
Heinrich Heine University of Duesseldorf, Duesseldorf, Germany
e-mail:
bernhard.homey@uni-duesseldorf.de