Approach

Summary

Licensing status

Publication and contact information

Disease models

Mouse model of neonatal intracranial hemorrhage

A mouse model of neonatal intracranial hemorrhage could be useful for developing therapies for the condition. In mice engineered to conditionally express VEGF in the brain, induction of VEGF during late embryonic development led to germinal matrix hemorrhage and intraventricular hemorrhage, two common forms of neonatal hemorrhage. In the mouse model, glucocorticoid treatment decreased VEGF-induced hemorrhage compared with no treatment. Next steps include exploring the therapeutic potential of antagonizing downstream effectors of VEGF signaling.

SciBX 6(31); doi:10.1038/scibx.2013.839
Published online Aug. 15, 2013

Patent and licensing status not applicable

Yang, D. et al. Sci. Transl. Med.; published online July 10, 2013;
doi:10.1126/scitranslmed.3005794
Contact: Chia-Yi Kuan, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio
e-mail:

alex.kuan@emory.edu