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Monoacyl lipopeptide agonist of toll-like receptor 2 (TLR2) as a vaccine adjuvant

A lipopeptide agonist of TLR2 could boost the efficacy of vaccines against infectious diseases. Chemical synthesis, SAR and in vitro testing of monoacyl lipopeptides identified a water soluble, nanomolar agonist of TLR2. In rabbits immunized with a vaccine based on the lactalbumin-a (Lalba) antigen or a diphtheria toxin antigen, coimmunization with the lead compound increased antigen-specific IgG levels in serum compared with coimmunization using vehicle. Next steps include testing the lead compound as an adjuvant to influenza vaccines in animals.

SciBX 6(29); doi:10.1038/scibx.2013.773
Published online Aug. 1, 2013

Patented; available for licensing

Salunke, D.B. et al. J. Med. Chem.; published online June 24, 2013;
doi:10.1021/jm400620g
Contact: Sunil A. David, The University of Kansas, Lawrence, Kan.
e-mail:
sdavid@ku.edu