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Using modified hyperbranched polyglycerol (HPG) to guide stem cell localization

Modified HPG could be used to target injected stem cells to specific tissues. HPG was modified with octadecyl chains and vasculature-binding peptides and then coated onto the surface of mesenchymal stem cells (MSCs). In an in vitro model for blood vessel circulation, MSCs coated with the modified HPGs showed greater adhesion to inflamed endothelium than MSCs coated with unmodified HPGs. Next steps include assessing the ability of the HPG carrier to guide cells to target tissues in vivo.

SciBX 6(20); doi:10.1038/scibx.2013.502
Published online May 23, 2013

Patent application filed; unavailable for licensing

Jeong, J.H. et al. J. Am. Chem. Soc.; published online April 16, 2013;
doi:10.1021/ja400636d
Contact: Hyunjoon Kong, University of Illinois at Urbana-Champaign, Urbana, Ill.
e-mail:
hjkong06@illinois.edu