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Antibody regions required for broadly neutralizing HIV antibody activity

In vitro and structural studies identified new regions of antibodies against HIV that could contribute to their broadly neutralizing activity. Somatic mutations were found more frequently in a panel of broadly neutralizing anti-HIV antibodies than in a panel of antibodies with more limited neutralizing activity. In broadly neutralizing antibodies, mutations in IgG structural framework regions were identified that do not make contact with HIV antigens but are still required for the broadly neutralizing activity. Next steps could include analyzing these regions when assessing responses to HIV vaccines.

SciBX 6(14); doi:10.1038/scibx.2013.350
Published online April 11, 2013

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Klein, F. et al. Cell; published online March 28, 2013;
doi:10.1016/j.cell.2013.03.018
Contact: Michel C. Nussenzweig, The Rockefeller University, New York, N.Y.
e-mail:
nussen@mail.rockefeller.edu