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Markers

N-Acetyltyramine-O,b-glucuronide (NATOG) as a biomarker for Onchocerca volvulus infection

Studies in human samples suggest NATOG could be a biomarker of onchocerciasis infection. In urine samples from African patients infected with the O. volvulus parasite that causes river blindness, liquid chromatography-mass spectrometry (LCMS)-based analysis of the urine metabolome showed that levels of NATOG, a neurotransmitter-derived metabolite from O. volvulus, were six times higher than levels in samples from healthy controls. Nest steps include designing antibodies against the biomarker.

SciBX 6(9); doi:10.1038/scibx.2013.228
Published online March 7, 2013

Unpatented; available for licensing

Globisch, D. et al. Proc. Natl. Acad. Sci. USA; published online Feb. 25, 2013;
doi:10.1073/pnas.1221969110
Contact: Kim D. Janda, The Scripps Research Institute, La Jolla, Calif.
e-mail:

kdjanda@scripps.edu