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Humanized mouse model for graft-versus-host disease (GvHD) prevention by Treg cells

A humanized mouse model for GvHD could be useful for testing the therapeutic potential of cultured human Treg cells. Previous studies in mice have suggested that adoptive transfer of allogeneic Treg cells could prevent GvHD. In the new study, human Treg cells were cultured ex vivo and transferred into mice with a humanized immune system. Mice receiving an immune cell fraction enriched with Treg cells had lower levels of proinflammatory cytokines and better survival than controls receiving nonspecific immune cells. Next steps could include scaling up production of Treg cells in preparation for clinical trials.

SciBX 6(5); doi:10.1038/scibx.2013.124
Published online Feb. 7, 2013

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Zheng, J. et al. Sci. Transl. Med.; published online Jan. 16, 2013;
doi:10.1126/scitranslmed.3004943
Contact: Wenwei Tu, The University of Hong Kong, Hong Kong, China
e-mail:
wwtu@hku.hk
Contact: Yu-Lung Lau, same affiliation as above
e-mail:
lauylung@hkucc.hku.hk