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Disease models

Mice with mesodermal inactivation of Pten (Mmac1; Tep1) as models for alveolar capillary dysplasia (ACD)

Mice with mesodermal inactivation of Pten could help identify new treatments for ACD, a congenitally lethal condition characterized by disordered pulmonary vascular development. Analysis of lung tissue samples from newborns who died from ACD showed decreased PTEN and increased protein kinase B (PKB; PKBA; AKT; AKT1) expression compared with newborns who died from other causes. Mice with pulmonary mesodermal-specific Pten inactivation had defects in lung development and failure in blood oxygenation and died at birth. Next steps include validating the model using samples isolated from infants affect by ACD.

SciBX 5(40); doi:10.1038/scibx.2012.1063
Published online Oct. 11, 2012

Unpatented; licensing status not applicable

Tiozzo, C. et al. J. Clin. Invest.; published online Oct. 1, 2012;
doi:10.1172/JCI61334
Contact: Parviz Minoo,
University of Southern California, Los Angeles, Calif.
e-mail:
minoo@usc.edu