Approach

Summary

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Disease models

Mice with conditional B cell-specific knockout of TANK-binding kinase 1 (Tbk1)

Mice with conditional B cell-specific knockout of Tbk1 could be useful for identifying new targets and treatments for autoimmune diseases. The Tbk1 knockout mice showed aberrant production of IgA and autoantibodies and deposition of antibodies in kidney glomeruli, which is a marker of nephropathy. A series of cell culture studies showed that TBK1 controlled IgA production via negative regulation of noncanonical NF-kB signaling. Next steps include further evaluating the role of TBK1 in regulating mucosal immunity and identifying associations between TBK1 deficiency and autoimmune diseases.

SciBX 5(39); doi:10.1038/scibx.2012.1040
Published online Oct. 4, 2012

Model unpatented; licensing details available from Lexicon Pharmaceuticals Inc.

Jin, J. et al. Nat. Immunol.; published online Sept. 30, 2012;
doi:10.1038/ni.2423
Contact: Shao-Cong Sun, The University of Texas MD Anderson Cancer Center, Houston, Texas
e-mail:

ssun@mdanderson.org