Thursday, September 20, 2012
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Assays & screens
High throughput screen for
inhibitors of lymphangiogenesis
A high throughput,
cell-based assay could be useful for identifying inhibitors of tumor
lymphangiogenesis, which is the aberrant growth of the lymphatic system that
can drive metastasis of solid cancers. Human dermal microvascular lymphatic
cells were coated onto beads, fluorescently labeled and cultured with test
compounds in a 96-well format. Automated fluorescence microscopy was then
used to quantify the reduction of lymphangiogenic sprouting associated with
each compound. Top hits identified with the assay were MEK
inhibitors and statin compounds. Next steps include
studying the effects of statins in a lymphangiogenesis tumor setting (see
bead on lymphangiogenesis, page 1).
Published online Sept. 20, 2012
status not applicable
Schulz, M.M.P. et al.
Proc. Natl. Acad. Sci. USA; published online
Sept. 4, 2012;
Contact: Michael Detmar, Swiss Federal Institute of
Technology Zurich (ETHZ), Zurich, Switzerland
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