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  • Techniques

    Approach Summary Licensing status Publication and contact information Assays & screens In vitro assay to screen for new inhibitors of leucine-rich repeat kinase 2 (LRRK2) An in vitro kinase assay could be useful…

    Published on 10/16/2014
  • Techniques

    Approach Summary Licensing status Publication and contact information Disease models Mouse models of non-small cell lung cancer (NSCLC) based on serial orthotopic transplantation of tumor tissue Mouse studies …

    Published on 10/16/2014
  • Techniques

    Approach Summary Licensing status Publication and contact information Disease models Patient-derived prostate organoids as prostate cancer models Prostate organoids derived from patient tumor cells could serve …

    Published on 10/16/2014
  • Techniques

    Approach Summary Licensing status Publication and contact information Drug platforms 3D matrix platform for generating mAbs to treat breast cancer A 3D matrix platform could be useful for generating mAbs to help…

    Published on 10/16/2014
  • Techniques

    Approach Summary Licensing status Publication and contact information Drug platforms Glycan recognition on HIV env by broadly neutralizing antibodies (bNAbs) Crystal structure analysis of bNAbs complexed with …

    Published on 10/16/2014
  • Techniques

    Approach Summary Licensing status Publication and contact information Drug platforms Small molecule-mediated ex vivo expansion of long-term repopulating progenitor cells in cord blood-derived hematopoietic stem …

    Published on 10/16/2014
  • Techniques

    Approach Summary Licensing status Publication and contact information Imaging Fluorescent PET imaging probe for hypochlorus acid (HClO) In vitro studies identified a fluorescent probe for HClO that could be …

    Published on 10/16/2014
  • Techniques

    Approach Summary Licensing status Publication and contact information Markers Gelsolin (GSN) as a marker for cisplatin sensitivity and patient survival in ovarian cancer Studies in patient samples and cell …

    Published on 10/16/2014
  • Techniques

    Approach Summary Licensing status Publication and contact information Assays & screens Single-molecular-interaction sequencing (SMI-seq) technology for multiplexed protein interaction profiling A method for …

    Published on 10/9/2014
  • Techniques

    Approach Summary Licensing status Publication and contact information Disease models Conditional ATG6 autophagy related 6 homolog (Becn1; Atg6) knockout mouse model of preterm labor Mouse studies suggest mice …

    Published on 10/9/2014
  • Techniques

    Approach Summary Licensing status Publication and contact information Disease models Mouse model of pain-associated anxiety and depression A mouse model of neuropathic pain could help identify therapeutics to …

    Published on 10/9/2014
  • Techniques

    Approach Summary Licensing status Publication and contact information Drug platforms Generation of insulin-producing cells from human embryonic stem cells (hESCs) to treat type 1 diabetes A protocol to generate …

    Published on 10/9/2014
  • Techniques

    Approach Summary Licensing status Publication and contact information Assays & screens Aqueous multiphase systems to test for sickle cell disease (SCD) Aqueous multiphase systems could be used to test patients …

    Published on 10/2/2014
  • Techniques

    Approach Summary Licensing status Publication and contact information Chemistry Reprogramming specificity of sortase enzymes A method to reprogram the substrate preference of sortase enzymes could help generate …

    Published on 10/2/2014
  • Techniques

    Approach Summary Licensing status Publication and contact information Chemistry Stabilized drug linker for antibody-drug conjugates (ADCs) In vitro and rodent studies suggest a stabilized drug linker in ADCs …

    Published on 10/2/2014
  • Techniques

    Approach Summary Licensing status Publication and contact information Chemistry Synthetic fermentation of bioactive b- peptide-based a-ketoamides In vitro studies suggest synthetic fermentation of bioactive b-…

    Published on 10/2/2014
  • Techniques

    Approach Summary Licensing status Publication and contact information Disease models Unadapted, pathogenic simian/human immunodeficiency viruses (SHIVs) to model AIDS Nonhuman primate studies suggest that newly …

    Published on 10/2/2014
  • Techniques

    Approach Summary Licensing status Publication and contact information Drug delivery Cyclodextrin-polymer nanoparticle delivery of combination siRNA payloads In vitro and mouse studies suggest cyclodextrin-…

    Published on 10/2/2014
  • Techniques

    Approach Summary Licensing status Publication and contact information Drug platforms Analyzing biosynthetic gene clusters of the human microbiome to identify antibiotics Systematic analysis of biosynthetic gene …

    Published on 10/2/2014
  • Techniques

    Approach Summary Licensing status Publication and contact information Drug platforms Structure-guided design of concentrative nucleoside transporter (CNT)-mediated therapies Structural data on CNTs could guide …

    Published on 10/2/2014
  • Techniques

    Approach Summary Licensing status Publication and contact information Chemistry Activity-directed synthesis of bioactive scaffolds Activity-directed synthesis could enhance the efficiency of bioactive scaffold …

    Published on 9/25/2014
  • Techniques

    Approach Summary Licensing status Publication and contact information Drug platforms Cell membrane-cloaked polymeric nanoparticles to clear autoreactive antibodies associated with autoimmune diseases …

    Published on 9/25/2014
  • Techniques

    Approach Summary Licensing status Publication and contact information Drug platforms Clustered, regularly interspaced short palindromic repeats (CRISPR)-Cas9 genome editing to cure latent viral infections CRISPR…

    Published on 9/25/2014
  • Techniques

    Approach Summary Licensing status Publication and contact information Drug platforms Cultured human muscle satellite cells to restore gene function in muscular dystrophies Cell culture and mouse studies suggest …

    Published on 9/25/2014
  • Techniques

    Approach Summary Licensing status Publication and contact information Imaging Nanoparticle-based imaging system using the metadherin (MTDH; AEG1) promoter to image prostate cancer A nanoparticle-based imaging …

    Published on 9/25/2014

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