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  • Techniques

    Approach Summary Licensing status Publication and contact information Assays & screens A refined, allele-specific quantitative PCR assay called Intplex for analysis of circulating cell-free DNA (cfDNA) mutations…

    Published on 4/17/2014
  • Techniques

    Approach Summary Licensing status Publication and contact information Assays & screens Tumor endothelial marker (TEM)-expressing circulating endothelial cells (CECs) as a blood-based marker to detect tumors and …

    Published on 4/17/2014
  • Techniques

    Approach Summary Licensing status Publication and contact information Chemistry Isoacyl dipeptides to increase insulin yield from chemical synthesis Chemical synthesis of insulin using isoacyl dipeptides could …

    Published on 4/17/2014
  • Techniques

    Approach Summary Licensing status Publication and contact information Drug platforms Binary nylon-3 copolymers containing cationic and hydrophobic subunits for antimicrobial activity In vitro studies identified …

    Published on 4/17/2014
  • Techniques

    Approach Summary Licensing status Publication and contact information Drug platforms Clustered, regularly interspaced short palindromic repeats (CRISPR)-based genome editing platform to treat genetic liver …

    Published on 4/17/2014
  • Techniques

    Approach Summary Licensing status Publication and contact information Drug platforms Mice with directed integration of human immunoglobulin transgenes to produce chimeric antibodies with fully human variable …

    Published on 4/17/2014
  • Techniques

    Approach Summary Licensing status Publication and contact information Markers Markers of distinct sonic hedgehog homolog (SHH)-driven medulloblastomas Mouse and sequencing studies suggest SHH-driven …

    Published on 4/17/2014
  • Techniques

    Approach Summary Licensing status Publication and contact information Markers MicroRNA-155 (miR-155) as a predictive marker of breast cancer response to radiation therapy In vitro and mouse studies suggest miR-…

    Published on 4/17/2014
  • Techniques

    Approach Summary Licensing status Publication and contact information Markers Mitochondrial DNA (mtDNA) mutations and impaired glucose utilization as markers of sensitivity to biguanides in cancer Cell culture …

    Published on 4/17/2014
  • Techniques

    Approach Summary Licensing status Publication and contact information Assays & screens Nanoparticles for in vivo detection of drug-induced hepatotoxicity Mouse studies suggest semiconducting polymer …

    Published on 4/10/2014
  • Techniques

    Approach Summary Licensing status Publication and contact information Assays & screens Polymerized antibody-tagged magnetic beads for isolation of circulating tumor cells (CTCs) Magnetic beads tagged with …

    Published on 4/10/2014
  • Techniques

    Approach Summary Licensing status Publication and contact information Assays & screens Protein misfolding cyclic amplification (PMCA) technique to create a-synuclein (SNCA) aggregates for drug screening In vitro…

    Published on 4/10/2014
  • Techniques

    Approach Summary Licensing status Publication and contact information Disease models Mice with human innate immune cells Humanized mice with functional human innate immune cells could be used as models to study …

    Published on 4/10/2014
  • Techniques

    Approach Summary Licensing status Publication and contact information Disease models Mouse model of amyotrophic lateral sclerosis (ALS) caused by partial loss of TAR DNA binding protein 43 (Tdp-43; Tardbp) …

    Published on 4/10/2014
  • Techniques

    Approach Summary Licensing status Publication and contact information Disease models Pituitary ablation of estrogen receptor expression as a mouse model for ovarian cancer A genetic mouse model for estrogen-…

    Published on 4/10/2014
  • Techniques

    Approach Summary Licensing status Publication and contact information Drug platforms Carbonic anhydrase IX (CAIX)-targeted small molecule-drug conjugates CAIX-targeted small molecule conjugates could be useful …

    Published on 4/10/2014
  • Techniques

    Approach Summary Licensing status Publication and contact information Drug platforms Crystal structure of purinergic receptor P2Y G protein-coupled 12 (P2RY12; P2Y12) bound to an antagonist In vitro structural …

    Published on 4/10/2014
  • Techniques

    Approach Summary Licensing status Publication and contact information Drug platforms Enhanced antigen-specific T cell activation using nanoscale artificial antigen-presenting cells (aAPCs) in a magnetic field In…

    Published on 4/10/2014
  • Techniques

    Approach Summary Licensing status Publication and contact information Drug platforms Small molecule inhibitors of microRNA processing An in vitro screening system could be used to identify small molecule …

    Published on 4/10/2014
  • Techniques

    This week in techniques Approach Summary Licensing status Publication and contact information Disease models Bioluminescent mouse model of HPV+ oral tumors to track the effect of therapeutics A bioluminescent …

    Published on 4/3/2014
  • Techniques

    This week in techniques Approach Summary Licensing status Publication and contact information Disease models Mouse model of dominant Ullrich congenital muscular dystrophy (UCMD) A mouse model of dominant UCMD …

    Published on 4/3/2014
  • Techniques

    This week in techniques Approach Summary Licensing status Publication and contact information Drug delivery Engineered, zinc finger domain-containing recombinases for site-specific delivery of therapeutic genes…

    Published on 4/3/2014
  • Techniques

    This week in techniques Approach Summary Licensing status Publication and contact information Drug platforms Crystal structure of metabotropic glutamate receptor subtype 1 (mGluR1; GRM1) The crystal structure …

    Published on 4/3/2014
  • Techniques

    This week in techniques Approach Summary Licensing status Publication and contact information Drug platforms Hexamer-forming mAbs that activate the complement system mAbs engineered with mutations that promote …

    Published on 4/3/2014
  • Techniques

    This week in techniques Approach Summary Licensing status Publication and contact information Drug platforms Mouse cardiomyocytes generated from fibroblasts with one pluripotency factor and four small molecules…

    Published on 4/3/2014

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