Targets & Mechanisms
Sponging out cystic fibrosis
Thursday, November 29, 2012
A Canadian team has found that compounds from sea sponges could be useful for treating cystic fibrosis. The compounds work in part by inhibiting a new family of targets for the disease: poly(ADP-ribose) polymerases. The researchers now plan to work backward to uncover why blocking these polymerases improves the function of CFTR, the mutated protein that causes CF.
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