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About a year after U.S. researchers developed small molecule inhibitors of the intractable target wild-type Ras, a Japanese team has identified compounds that hit Ras mutant tumors in mice. The team now is trying to …
Published on 5/16/2013
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Targets & Mechanisms: AD vaccine redux Table 1. Alzheimer's disease vaccine pipeline. At least seven vaccines against b-amyloid (Ab) are in preclinical through Phase II testing to prevent AD. Source: BCIQ: …
Published on 5/9/2013
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Researchers at Harvard have teamed up with Mercia to design a next-generation Alzheimer's disease vaccine. The beta-amyloid-targeted formulation features an adjuvant that promotes a beneficial anti-inflammatory response…
Published on 5/9/2013
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An Albert Einstein College of Medicine team has used radiolabeled Listeria monocytogenes to treat metastatic pancreatic cancer in mice. Future studies could involve comparing or combining the strategy with existing …
Published on 5/2/2013
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Sanofi and Flanders Institute for Biotechnology researchers have discovered a molecule that inhibits FGFR allosterically instead of orthosterically. The pharma is developing analogs of the inhibitor for cancer.
Published on 5/2/2013
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Targets & Mechanisms: MERTK: upstream from BRAF Figure 1. Downstream of MERTK. According to a study in The Journal of Clinical Investigation, inhibiting c-Mer proto-oncogene tyrosine kinase (MERTK)-which lies …
Published on 4/25/2013
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Separate teams at the Scripps Research Institute and UCLA have shown that blocking type I interferon can resolve viral infections in mice. The findings suggest that interferon treatment of viral infections, although …
Published on 4/25/2013
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U.S. researchers have shown that inhibiting c-Mer proto-oncogene tyrosine kinase, a protein that sits upstream from BRAF, reduced melanoma growth in mice. Future studies will need to determine whether inhibitors of this…
Published on 4/25/2013
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Agios has reported the first mutant-selective inhibitors of the metabolic enzymes IDH1 and IDH2 and has shown therapeutic effect in preclinical cancer models. The company has a partnership with Foundation Medicine to …
Published on 4/11/2013
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A Japanese team has provided new structural insights into the function of a conserved class of drug transporters. The researchers are collaborating with PeptiDream to develop cyclic peptide inhibitors that hit medically…
Published on 4/11/2013
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Glutamine metabolism drives PDAC Figure 1. Glutamine metabolism. Cancer cells are dependent on specific metabolic pathways, such as glutamine metabolism, to supply excess energy that sustains cell growth and …
Published on 4/4/2013
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Dana-Farber researchers have identified a glutamine metabolism pathway activated by oncogenic K-Ras in pancreatic cancers. The team found three different enzyme targets within the pathway that could be targeted to …
Published on 4/4/2013
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Baylor College of Medicine researchers have shown that delivering the gene for proteoglycan 4 to the knee prevented and treated osteoarthritis in mice. GeneQuine has exclusively licensed the findings and is developing a…
Published on 4/4/2013
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Researchers at Eureka Therapeutics and Memorial Sloan-Kettering have targeted Wilms tumor 1-positive cancer cells with a mAb against peptide fragments derived from the protein that are presented on the cells' surface. …
Published on 3/28/2013
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University of Colorado researchers have shown that topical application of the signaling protein Smad7 can treat and prevent oral mucositis in mice. The team will now test the compound in mice with cancer-associated …
Published on 3/28/2013
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A team from The University of British Columbia has used a mechanism-based approach to design irreversible inhibitors of influenza virus neuraminidase. The compounds are being developed by the venture arm of The Centre …
Published on 3/21/2013
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Researchers from The University of Alabama at Birmingham have shown a therapeutic effect of Rho kinase inhibitors in idiopathic pulmonary fibrosis. Although the results suggest a repurposing opportunity for the …
Published on 3/21/2013
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Understanding fibrosis Figure 1. Myofibroblast dynamics. Lung fibroblasts undergo actin cytoskeleton and actomyosin contractile system remodeling in response to biomechanical and biochemical stimuli. This remodeling …
Published on 3/21/2013
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Understanding fibrosis Table 1. TGFB1 and Rho kinase inhibitors. Transforming growth factor-b1 (TGFB1) inhibitors Company Product Disease category Indication Development InterMune Inc. (NASDAQ:ITMN) Esbriet …
Published on 3/21/2013
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Targets & Mechanisms: Placing kinases in the WNT pathway Figure 1. WNT signaling in cancer. A Boston-based team and a Genentech Inc.-led team have each identified a new kinase-v-yes-1 Yamaguchi sarcoma viral oncogene…
Published on 3/14/2013
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A Boston-based team and a group led by Roche's Genentech unit have each identified new kinase regulators of WNT signaling-YES1 and RIPK4, respectively-that provide two new, druggable targets. Each team will now look for…
Published on 3/14/2013
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Separate teams from New York University and Columbia University have identified mutations in NT5C2 that predict relapse, drug resistance and poor prognosis in ALL. Inhibiting the enzyme could help sensitize some …
Published on 3/7/2013
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German and U.S. researchers have shown that intra-adrenal transplantation of islet cells preconditioned with an improved peptide agonist of GHRH may normalize glucose levels in diabetic mice better than existing …
Published on 2/28/2013
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Researchers at the Penn State Milton S. Hershey Medical Center have identified a small molecule inducer of TRAIL expression that has antitumor effects in multiple mouse models. Oncoceutics has licensed the findings and …
Published on 2/28/2013
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Harvard Medical School researchers have shown that the plant-derived small molecule huperzine A can reduce neuropathic pain in mice with spinal cord injury. Insero Health has licensed IP covering epilepsy and …
Published on 2/21/2013