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2012 gets a new deal Table 3. Top public-private partnerships in 2012 by value. Two of the five largest 2012 public-private partnerships (PPPs) without direct government support were valued at $100 million or more. …
Published on 2/7/2013
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SciBX's second annual global analysis of public-private partnerships and early stage venture financing activity reveals that government institutions are taking a significant role in forming and funding PPPs, and …
Published on 2/7/2013
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Five separate research teams have developed a Cas9 endonuclease-based method for sequence-specific genome modification. Although the approach is technically more straightforward than existing methods, its specificity …
Published on 1/31/2013
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A Dundee-UNC team has created a computational algorithm that mines medicinal chemistry literature to predict new ligands that bind specific combinations of GPCRs. Ex Scientia was spun out of Dundee to commercialize the …
Published on 1/24/2013
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Washington University in St. Louis School of Medicine researchers have used next-generation sequencing to identify mutations in HER2 that are missed by standard screening tests. Based on the findings, the researchers …
Published on 1/17/2013
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Amgen researchers have developed an antibody that mimics fibroblast growth factor 21 and has antidiabetic effects in monkeys. The findings cap a year of advances that have greatly increased understanding of the protein'…
Published on 1/10/2013
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mAb about FGF21 Figure 1. FGF21 gets detailed. Researchers from Amgen Inc. and Roche's Genentech Inc. unit have separately published studies that suggest using antibodies to mimic fibroblast growth factor 21 (FGF21) …
Published on 1/10/2013
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CureVac and the Friedrich Loeffler Institute have in vivo evidence that an mRNA-based vaccine can prevent influenza A infection. The results provide proof of concept for the company's vaccine platform in infectious …
Published on 12/20/2012
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Researchers at McGill University have mouse data showing a causal link between eIF4E-mediated translational dysregulation and autism-related deficits. The group also corrected the dysregulation-and the associated …
Published on 12/13/2012
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A European team has used the diabetes drug glibenclamide to block inflammation-induced neurodegeneration in mice. The team plans to test the nonspecific inhibitor of the cationic channel TRPM4 in an investigator-led …
Published on 12/6/2012
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Researchers at the Mater Medical Research Institute, The University of Queensland and GlycoMimetics have mouse data showing that E selectin antagonists can alleviate side effects of chemotherapy brought about by …
Published on 11/29/2012
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Multitasking E selectin Box 1. More repurpose. An Indiana University School of Medicine team has shown that the diabetes drug Januvia sitagliptin can enhance the recovery of hematopoietic stem and progenitor cells …
Published on 11/29/2012
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Cover Story: Bringing macrocycles full circle Box 1. SciBX innovation summits launched. This week, SciBX is publishing the first Roadmap for Innovation resulting from a SciBX Summit on Innovation in Drug Discovery…
Published on 11/15/2012
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Cover Story: Bringing macrocycles full circle Figure 1. Recent company and partnership formation trends in the macrocycle space. Although company formation in the macrocycle space has been relatively steady since …
Published on 11/15/2012
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The first SciBX Summit on Innovation in Drug Discovery & Development, held in Boston in September, addressed the opportunity afforded by macrocycles and constrained peptides to open up vast new therapeutic target space,…
Published on 11/15/2012
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Researchers at Yale have found that a lupus-related autoantibody sensitizes cancer cells to DNA-damaging radiation and chemotherapy. The antibody, which has already proven safe in a clinical trial in SLE, may be …
Published on 11/8/2012
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A trio of papers has provided new hints on how best to use activators of PKM2, a target involved in cancer cell metabolism. Astex is using its findings to steer an early stage PKM2 program, whereas Agios is remaining …
Published on 11/1/2012
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German researchers have shown that melanoma cells can acquire resistance to adoptive T cell transfer therapies by dedifferentiating themselves to hide antigens. The group now is trying to circumvent this resistance …
Published on 10/25/2012
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Melanoma's hidden act Figure 1. Resistance to adoptive T cell therapy via dedifferentiation. As reported by Landsberg et al., melanoma cells can undergo inflammation-induced dedifferentiation. The process is a …
Published on 10/25/2012
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UT Southwestern Medical Center researchers have shown that an antibody targeting endotrophin, a fat cell-derived extracellular protein, reduced growth of breast tumors in mice. The team will next study the antibody in …
Published on 10/18/2012
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Cover Story: Taking the fat out of cancer Figure 1. Targeting endotrophin in breast cancer. Researchers from The University of Texas Southwestern Medical Center published in The Journal of Clinical Investigation that…
Published on 10/18/2012
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Boston-area researchers have shown that inhibiting a cation channel dubbed TRPV4 induced white fat cells to behave like brown fat, thereby protecting mice from diet-induced obesity and insulin resistance. Ember …
Published on 10/11/2012
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NIH researchers have shown that sphingosine 1-phosphate receptor agonists such as Novartis' Gilenya could transiently reduce P glycoprotein-mediated drug efflux and enhance drug delivery to the brain. The group is …
Published on 10/4/2012
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A Columbia University team has evidence that pancreatic islet Beta cells do not die but rather dedifferentiate in mouse models of type 1 and type 2 diabetes. The findings suggest a therapeutic strategy of reawakening …
Published on 9/27/2012
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A team of German researchers has developed a high throughput assay to identify compounds that block lymphangiogenesis, a process that promotes the progression and metastasis of solid tumors. Some of the top hits were …
Published on 9/20/2012