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Chronological Index of : Cover Story

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  • Figure 2: Receptor expression and engagement of antigen

    Cover Story: Keys to the CAR Figure 2. Receptor expression and engagement of antigen. (I) T cell receptors (TCRs) consist of a heterodimer of a- and b-chains that associate with the g-, d-, e- and z-chains of the CD3…

    Published on 6/26/2014
  • Breaking MYC metabolism

    The metabolic enzyme PRPS2 could represent a tractable way to modulate the notoriously undruggable oncogene MYC. The findings from a UCSF team are licensed to Effector Therapeutics and provide a clue as to how the …

    Published on 6/19/2014
  • Nav-i-gating antibodies for pain

    Nav1.7 entered the scene a decade ago as a pain target with wide-ranging analgesic effects, but it has been difficult to selectively target. Now, a team at Duke has succeeded with an antibody that blocks the channel in …

    Published on 6/12/2014
  • Table 1: Nav1.7 small molecule inhibitors and antibodies

    Cover Story: Nav-i-gating antibodies for pain Table 1. Nav1.7 small molecule inhibitors and antibodies. Specifically blocking the Nav1.7 (SCN9A) voltage-gated sodium channel subtype suppresses pain. At least six …

    Published on 6/12/2014
  • Alas, porphyria

    Treatment of acute porphyrias has long relied on hemin infusions, but the therapy has many drawbacks. A team led by Alnylam has created an siRNA therapeutic that reduces disease symptoms in mice. The company still needs…

    Published on 6/5/2014
  • Personalized medicine gets personal

    Epithelial cancers are the most common malignancies, but immunotherapy development has been stymied because the low mutation frequency of these tumors elicits muted mutation-specific T cell responses. An NCI team has …

    Published on 5/29/2014
  • Ob(nox)ious fibrosis

    Although the most advanced drug for idiopathic pulmonary fibrosis has shown a mortality benefit, the effects are modest and there remains room for improvement. New preclinical findings suggest inhibiting NOX4 could both…

    Published on 5/22/2014
  • Table 1: Select clinical-stage compounds that target epigenetic regulators

    Cover Story: Chromatin's rising tide Table 1. Select clinical-stage compounds that target epigenetic regulators. The availability of new research tools and data on epigenetic regulators has driven the development of …

    Published on 5/15/2014
  • Chromatin's rising tide

    At the SciBX Summit on Innovation in Drug Discovery, participants laid out a road map for how to capitalize on the full range of possible chromatin targets in and beyond oncology. They determined that industry and …

    Published on 5/15/2014
  • Figure 1: Blocking androgen signaling in castration-resistant prostate cancer

    Cover Story: BETting on OncoFusion Figure 1. Blocking androgen signaling in castration-resistant prostate cancer. Nearly all pathways associated with the transition from androgen-dependent to castration-resistant …

    Published on 5/8/2014
  • BETting on OncoFusion

    Medivation has licensed a portfolio of BET bromodomain inhibitors that could have better efficacy than the company's castration-resistant prostate cancer drug Xtandi enzalutamide. Medivation got the molecules from …

    Published on 5/8/2014
  • Peeking inside AMD

    Conflicting results from prior studies made it unclear whether IL-18 was a cause of or a potential therapy for age-related macular degeneration. A tiebreaker study suggests the latter, showing that the cytokine was at …

    Published on 5/1/2014
  • CRISPR in the liver

    Although the therapeutic utility of CRISPR-based approaches has yet to be demonstrated, venture dollars are flowing into new companies developing the platform. Proof of concept may come faster than expected as new …

    Published on 4/24/2014
  • Contaminating cancer genomes

    Two European teams have pinpointed a DNA-protective enzyme as a chemically tractable target whose inhibition kills cancer cells by accelerating DNA damage. Both groups have identified small molecule inhibitors of the …

    Published on 4/17/2014
  • Pre-EMP-tive strike against GBM

    UCLA researchers have treated glioblastoma in mice by inhibiting EMP2. The findings open up a new indication for spinout Paganini, which has a mAb against the target in development for triple-negative breast cancer.

    Published on 4/10/2014
  • Table 1: EMP2's downstream crowd

    Cover Story: Pre-EMP-tive strike against GBM Table 1. EMP2's downstream crowd. University of California, Los Angeles researchers have shown that in mouse models of glioblastoma multiforme (GBM) and breast cancer, …

    Published on 4/10/2014
  • Critical mass in diabetes

    A University of Bremen group has found a new target-STK4-that can increase beta cell mass and may provide an alternative to invasive islet cell transplants to treat diabetes. The team will need to rule out long-term …

    Published on 4/3/2014
  • A bitter taste for sinus infections

    A University of Pennsylvania study has shown that bitter taste agonists stimulate the release of antimicrobial peptides in the sinuses, suggesting a new way to treat chronic rhinosinusitis. Although taste receptor-…

    Published on 3/27/2014
  • A liver divided

    Three independent teams have directly converted human fibroblasts to liver cells and eliminated a proliferation barrier from stem cell-based protocols.

    Published on 3/20/2014
  • Killer targets in metastasis

    An international team has found a new pathway in NK cells that leads to the rejection of metastatic tumors. It remains unclear which components of the pathway will make the best targets.

    Published on 3/13/2014
  • Box 1: The development and validation of LDC1267

    Cover Story: Killer targets in metastasis Box 1. The development and validation of LDC1267. In 2008, Axel Ullrich and co-workers published evidence that the TAM receptor family protein AXL receptor tyrosine kinase (…

    Published on 3/13/2014
  • Figure 1: Strategies to activate antitumor NK cells

    Cover Story: Killer targets in metastasis Figure 1. Strategies to activate antitumor NK cells. NK activation occurs downstream of killer cell lectin-like receptor subfamily K member 1 (KLRK1; CD314; NKG2D). In Nature…

    Published on 3/13/2014
  • Liver X receptor marks the spot

    A New York team and Rgenix have found that LXR agonists can treat metastatic melanoma. The findings open up new therapeutic real estate for LXR agonists that pharma companies discontinued in cardiovascular disease.

    Published on 3/6/2014
  • Table 1: Participants in the NIH AMP consortium

    Cover Story: AMPlifying targets Table 1. Participants in the NIH AMP consortium. The NIH has formed a public-private partnership, called the Accelerating Medicines Partnership (AMP), with industry and not-for-profit …

    Published on 2/27/2014
  • AMPlifying targets

    The NIH has joined with over 15 companies and not-for-profit organizations to create the Accelerating Medicines Partnership, a public-private partnership focused on discovering new targets and biomarkers for 4 diseases.…

    Published on 2/27/2014

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