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Temodal, Temodar, temozolomide

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Company Cancer Research Technology Ltd.
DescriptionImidazotetrazine cytotoxic alkylating agent
Molecular Target DNA
Mechanism of ActionBreaks/crosslinks DNA
Therapeutic ModalitySmall molecule
Latest Stage of DevelopmentMarketed
Standard IndicationBrain cancer
Indication DetailsFirst-line treatment for newly diagnosed glioblastoma multiforme (GBM); Treat glioblastoma multiforme (GBM); Treat high-grade glioma; Treat malignant glioma; Treat newly diagnosed glioblastoma multiforme (GBM) and refractory malignant gliomas, such as anaplastic astrocytoma; Treat newly diagnosed glioblastoma multiforme (GBM) in combination with radiotherapy; Treat refractory anaplastic astrocytoma
Regulatory Designation
Partner Merck & Co. Inc.

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