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Nalbuphine ER (T111)

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Company Endo International plc
DescriptionExtended-release oral formulation of nalbuphine, a mu opioid receptor (OPRM1; MOR) antagonist and kappa opioid receptor agonist
Molecular Target Mu opioid receptor (OPRM1) (MOR) ; Kappa opioid receptor (OPRK1) (KOR)
Mechanism of Action 
Therapeutic ModalitySmall molecule
Latest Stage of DevelopmentPhase I
Standard IndicationItch
Indication DetailsTreat chronic uremic pruritus; Treat hemodialysis-related uremic pruritus
Regulatory Designation


Trevi Therapeutics Inc.

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