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Nalbuphine ER (T111)

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Company Endo International plc
DescriptionExtended-release oral formulation of nalbuphine, a mu opioid receptor (OPRM1; MOR) antagonist and kappa opioid receptor (OPRK1; KOR) agonist
Molecular Target Mu opioid receptor (MOR) (OPRM1) ; Kappa opioid receptor (KOR) (OPRK1)
Mechanism of ActionKappa opioid receptor agonist; Mu opioid receptor antagonist
Therapeutic ModalitySmall molecule
Latest Stage of DevelopmentPhase II/III
Standard IndicationItch
Indication DetailsTreat hemodialysis-related uremic pruritus; Treat prurigo nodularis
Regulatory Designation
Partner Trevi Therapeutics Inc.

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