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Careram, Kolbet, Iguratimod (T-614)

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Company Toyama Chemical Co. Ltd.
DescriptionDMARD that inhibits the production of IL-1, IL-6, IL-8 and tumor necrosis factor (TNF)
Molecular Target Nuclear factor of kappa light polypeptide gene enhancer in B cells 1 (NF-kB) (NFKB1) (p105) (p50)
Mechanism of ActionNF-kappa B (NF-kB) inhibitor
Therapeutic ModalitySmall molecule
Latest Stage of DevelopmentMarketed
Standard IndicationRheumatoid arthritis (RA)
Indication DetailsTreat rheumatoid arthritis (RA)
Regulatory Designation
PartnerEisai Co. Ltd.;
Taisho Pharmaceutical Holdings Co. Ltd.

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