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synNotch T cells

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Company University of California San Francisco
DescriptionT cells engineered to express a synthetic Notch receptor composed of modular, custom-selected extracellular sensing and intracellular response domains which can be programmed to produce therapeutic agents in the presence of disease-specific molecular cues
Molecular Target
Mechanism of Action 
Therapeutic ModalityCell therapy: Non-stem cell
Latest Stage of DevelopmentPreclinical
Standard IndicationChronic myelogenous leukemia (CML)
Indication DetailsTreat chronic myelogenous leukemia (CML)
Regulatory Designation
PartnerCell Design Labs Inc.

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